Re: Merck's PIII Prostate trial, not the one with ZEN-3694, is halted for not showing improvement vs control

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Zenith's BET Inhibitor ZEN-3694 is Currently Being Evaluated in Multiple Oncology Clinical Trials

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KOO-KOO2

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Re: Merck's PIII Prostate trial, not the one with ZEN-3694, is halted for not showing improvement vs control

in response to

Re: Merck's PIII Prostate trial, not the one with ZEN-3694, is halted for not showing improvement vs control

KayakerBC

posted on Jan 27, 2023 09:55AM

My guess is that they hope for better results by dropping the androgen-deprived therapy and adding the BET Bromodomain Inhibitor ZEN-3694.

PubMed: "BET bromodomain inhibitors block prostate cancer cell growth at least in part through c-Myc and androgen receptor (AR) suppression."