Thanks Bfw for sharing you insight on spironolactone and statins. I have a more strict definition of anti-androgen, which statins do not fit. If it doesn't potently suppress steroid hormone synthesis (i.e. like a CYP17A1 or CYP19A1 inhibitor) and if it doesn't strongly interfere with androgens binding to the androgen receptor, then I don't call it an anti-androgen. Can statins have some pleiotropic effect on steroid hormone biology in addition to its effects to decrease cholesterol synthesis and increase LDL receptor levels? Sure. But to call it an anti-androgen is an insult to the real deal anti-androgens out there like enzalutamide, abiraterone, etc. LOL.

Would you at least agree that there is no published/public data supporting any connection of apabetalone/RVX-208 to androgen synthesis, androgen binding to androgen receptor, or post-receptor binding signaling?

BearDownAZ