Tada,

Thanks for the additional insight on the adjudication and follow up timelines. Very helpful. Also, you wrote "All in all IMO it is a good thing that events are not occurring at the predicted rates. It would be best if that is as a direct result of patients on 208 are having few if any events at all."

Keep in mind that with 250 events, this would be the apabetalone/placebo event split to get the corresponding %RRR. So the apabetalone group can still experience more than a few events and BETonMACE would still achieve an astronomical %RRR.

110/140 = 21.4% RRR

100/150 = 33.3% RRR

90/160 = 43.7% RRR

75/175 = 57.1% RRR

50/200 = 75% RRR

BearDownAZ