"Is it possible that RVX and the FDA have already agreed to changes and BetonMace is now proceeding with those changes in place? … would they put out a nr? … or will we have to wait for trials.gov to update their site? … anybody know how often they do update their site?"

I expect both a news release and updates to the ClinicalTrials.gov page. There is often a couple or few days lag time in between when the update is submitted to ClinicalTrials.gov and when it appears on the website.