Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer
https://www.ncbi.nlm.nih.gov/pubmed/29949494
"Among men with nonmetastatic, castration-resistant prostate cancer with a rapidly rising PSA level, enzalutamide treatment led to a clinically meaningful and significant 71% lower risk of metastasis or death than placebo."
This would actually be really good for Zenith's combo therapy. More patients on enzalutamide equals more patients developing enzalutamide resitance = more opportunity for ZEN-3694/enzalutamide combo