Hi Bear,

Thank you for the detailed information on the zenith trial, I have a simple question to ask since you have a great science background and I do not. Since this trial is not blinded I want to know if the trial would have been stopped 100% if it was showing absolutely no efficacy at all and if they were major safety issues.  Since the trial continues I would asssume that there has to be some sort of effacacy or why continue the trial ???