Nature Medicine article "Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas"

"All together, our data provide strong support for the use of BET inhibitors as a promising therapeutic strategy in DIPG......In conclusion, our work provides important molecular insights about H3K27M function in DIPG oncogenesis, and identifies PRC2 and BET bromodomain proteins as potential therapeutic targets for this disease."

Science Daily write up "Molecule stops fatal pediatric brain tumor"

"To the best of our knowledge, this is the most effective molecule so far in treating this tumor," said senior author Ali Shilatifard, the Robert Francis Furchgott Professor of Biochemistry and Pediatrics and the chair of biochemistry and molecular genetics at Feinberg. "Every other therapy that has been tried so far has failed."