PVLee,
Most of your questions can be answered by looking at the Eligibility Inclusion criteria for the two trials NCT02705469 and NCT02711956. In terms of seeing results "quickly by virtue of those patients hopefully still being with us" remember that the first step is dose-escalation of ZEN003694 in 28 day cycles to determine optimal dose for efficacy and dose-limiting toxicities. But yes, patient survival would be a great indication that it's working.
BearDownAZ