"Hi xxx,

Formal hypothesis testing for BETonMACE’s primary outcome measure was calculated by log-rank test (full methodological details can be found here:https://jamanetwork.com/journals/jama/fullarticle/2763951). Statistical analysis plans (SAPs) for our clinical trials are prepared in consultation with expert, third-party statisticians as well as regulators, such as the US FDA.

Best regards,

Chris"