apabetalone vs JAK inhibitors
posted on
Mar 01, 2023 10:57AM
From the new publication:
"Baricitinib is a JAK inhibitor that counters cytokine signaling and has been approved for COVID-19 emergency use as an anti-inflammatory therapeutic [54]. Baricitinib at a non-toxic concentration (Fig S1) lowered poly I:C-induced CXCL10 gene expression to a similar extent as apabetalone at 5 μM. Interestingly, in contrast to BETi, this JAKi treatment had no effect on CCL2 expression, and upregulated IL1B mRNA levels by ∼ 42% (p = 0.001, Fig. 2). Overall, while both BETi and baricitinib downregulated the transcription of CXCL10 and IL6, BETi also reduced the expression of CCL2 and IL1B, suggesting superior anti-inflammatory potential in response to viral RNA-like stimuli."
IMO, and in the opinion of a dozen PHDs, Apabetalone is safe and way more effective than FDA-approved baricitinib (Olumiant). FDA approved it for arthritis a few years back and also for hospitalized Covid-19 patients. There are some concering side-effects to Olumiant too.
https://www.fiercepharma.com/pharma/fda-converts-eua-lillys-olumiant-full-nod-hospitalized-covid-19-patients
"Nearly one million people in 15 countries have been treated with Olumiant since the outset of the pandemic, Eli Lilly said.
During that time, sales of the drug have increased steadily—from $427 million in 2019 to $639 million in 2020 and $1.115 billion last year. Last month, Lilly reported first quarter sales of Olumiant at $256 million, an increase of 32% from the first quarter of 2021. The drug has been used much more outside of the U.S. In 2021, for example, 29% of its sales were domestic.
The approval was based on two trials—one where Olumiant was used in conjunction with Veklury and the other where it was used as a standalone. Both studies showed the ability of the drug to reduce the risk of death and the length of hospitalization."
(my highlighting)