100 days to engineer.  Then undergo testing.   Money v no money!  Possible five to six months.

BioNTech (the Pfizer vaccine) says "it could produce and ship the updated version of its vaccine within 100 days if the new Covid variant detected in southern Africa is found to evade existing immunity."

(BioNTech says it could tweak Covid vaccine in 100 days if needed, The Guardian.  (my bolding))

Though it would take months after that to poke all the folks who want it.

If the current vaccines don't protect very well against Omicron, it increases the potential pool of patients for apabetalone, but the primary target patients will be the unvaccinated.  Those are the majority of the folks who end up in the hospital.