Re: NAFLD
posted on
May 27, 2021 11:31AM
Apparently upwards of 70% of type 2 diabetics have NAFLD. Of those type 2 diabetics with NAFLD, about half have NASH and 1/3 have significant liver fibrosis: https://www.niddk.nih.gov/health-information/professionals/diabetes-discoveries-practice/fatty-liver-disease-an-underdiagnosed-complication-of-type-2-diabetes
Thanks for the great post Jonzobot!
For the scientific DD junkies out there: my DD file didn't come up with much for "apabetalone for Non-alcoholic fatty liver disease" except I did find the following on Non-alcoholic Steatohepatitis (NASH) which is "affiliated" with NFLD.
NASH (Non-alcoholic Steatohepatitis)
https://www.nature.com/articles/s41598-018-35653-4
https://www.nature.com/articles/d41573-019-00086-9
Nlrp3 and the inflamasome activation (Parkinsons, Alzheimers, gout)
"NLRP3 has also been linked via preclinical data with nearly two dozen other conditions — including atherosclerosis, Alzheimer disease, gout, Parkinson disease, rheumatoid arthritis and non-alcoholic steatohepatitis (NASH).
“All the big pharma companies want to block this target. It ticks all the boxes,” says O’Neill.""
BTW, ladies and gentlemen....Apabetalone down-regulates NLRP3.
https://www.investors.com/news/technology/nash-liver-disease-treatment-biotech-companies-billions-sales/