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Message: Re: Success or Failure?
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Oct 05, 2019 10:24PM

"What I'm wondering is if its possible that BETonMACE actually could be said to have passed the Primary Endpoint?....Could the results for the Primary Endpoint likewise be proven, except by a textbook and/or academic definition?"

I 100% agree. For all we know, there might have been just a near miss on hitting statistical significance. The threshold for significance is p<0.05. Perhaps BETonMACE achieved p=0.052 or p=0.06 or something like that. Significance thresholds for determining success are somewhat arbitrary. BETonMACE could have achieved an amazing %RRR but with a p-value just missing the cut off. With our limited information available, that scenario is just as likely as a complete miss with minimal to any %RRR and very bad p-value. Here's a good reference on the history of the p<0.05 threshold.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169785/

BDAZ

 

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