Cancun ... I like those numbers and time-frames also, based STRICTLY on positive Cardio TLD/FLD.

But I think it could/should be a little higher post-AHA (FLD) and for a buyout "if" secondary looks positive also. As tada and some others have pointed out, those additional markets of Renal & Cognitive represent even larger opportunities (potentially). Plus the "goodwill" of the all the research, people/scientists, and entire library of molecules potentially ... and there seems to be a continually widening of interest and understandings of application for this science well beyond the currently studied applications.

But I do like your pragmatic market approach with RVX, and surmisal for cardio! All "IMHO's" of course, not speculating.