"Mutation-free genes that you were born with can one day mutate in response to environmental, diet and lifestyle factors..The great news is Apabetalone safely reverses these mutation, restoring your cells according to their original gene expression."

There is little to any evidence that chronic diseases (for example diabetes, obesity, cardiovascular disease, renal disease, neurodegenerative disease) are due to new mutations that occur after a person is born. It seems you are confusing genetic changes (DNA mutations) with the epigenetic changes (no change to DNA sequence) that result in abnormal changes to the expression level of key genes that contribute to the disease. While apabetalone seems to restore normal levels of gene expression, apabetalone does not reverse any mutations. Apabetalone binds to the bromodomains (BD2 more than BD1) of BET proteins to prevent these BET bromodomains from binding to acetylated lysine residues on the histones of the DNA/chromatin structure. By inhibiting this acetylated-lysine binding, or reading, apabetalone prevents the BET bromodomain protein from being recruited there and helping to activate transcription. In this way, apabetalone cools off the abnormally high transcription of certain genes characteristic of that disease state. Nothing to do with causing or fixing mutations.

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