I should add one more:

4) The BETonMACE top-line data announcement may also include teasers on the results of the CKD and cognition sub-studies for eGFR and MoCA changes, respectively. So even if full details of the CKD and cognition studies aren't revealed in top-line, reporting a statistically significant improvement in one or both, even without the magnitude of the effect size) will still be a huge statement.

BearDownAZ