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Message: BRD4/Nrf2/ARE signaling is implicated in the pathogenesis of diabetic nephropathy

It's a little slow on the board today, so I thought I'd post this article abstract I saw the other day. I don't have access to the article. They use the pan-BET inhibitor JQ1, but this may still be a relevant mechanism for the renal protective effects of bromdomain-2 selective apabetalone.

BRD4 contributes to high-glucose-induced podocyte injury by modulating Keap1/Nrf2/ARE signaling

https://www.ncbi.nlm.nih.gov/pubmed/31325480

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