Just a small point....Bear, you said:

"And we shouldn't expect any BETonMACE trial data (cardio, cognition, or renal) prior to top-line data, in my opinion".

The PR said: "Approximately two weeks after DBL – currently projected for within September 2019 – top-line results (i.e. primary *and selected secondary endpoints) are expected to be announced..." *emphasis is mine

I believe that could mean a simple announcement about secondary CKD and Cognition measures, maybe something like:  "Results show significant improvement in eGFR for Kidney patients and in MOCA scores of those patients aged 70 years and more".

Of course we don't know what "selected" secondary endpoints might be released...I've been focused on secondary outcomes for CKD and Cognition.  Are there others?