BETonMACE was designed with a projection that apabetalone would elicit a 30% RRR. However,  the 30% RRR was just a placeholder for trial design and trial statistical powering issues. ANY %RRR that is statistically significant between the placebo and apabetalone groups for the primary endpoint will mean that BETonMACE is successful and has met the primary endpoint. The chance of a small trial like this achieving a statistically significant difference between the placebo and apabetalone groups will be greater with a more impressive %RRR. However, %RRR values less that 30% are still successful as long as statistically significant.

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