"I know Bear will beat me up on this point (perhaps standard of care means MACE rates for all go down, including for the placebo group etc)...still 42 months instead of 36 months is an extra 1000  patient years right there.  Far more than what the 30% RRR assumption would have predicted."

You are assuming that there were no delays in enrollment that would slow down patient year accumulation. Unless you know for sure that the trial exceeded the originally planned 3600 patient years, then the 42 months vs. 36 months is not very helpful.

BearDownAZ