VCAM-1 getting a lot of attention lately as a target for neuroinflammation and neurodegeneration.

VCAM1 As a Player in the Aging Brain, by Derek Lowe

By disabling a protein in the brain’s blood vessels, researchers ease age-related deterioration in mice, by Andrew Joseph of STAT news.

Apabetalone has been shown in several studies to decrease VCAM-1. Very exciting. Apabetalone SMASH inflammation! Thanks to rndtbl over on Investor Village for starting this VCAM-1 discussion.

The Epigenetic Inhibitor Apabetalone Downregulates Brain Endothelial and Microglial Cell Activation that Contributes To Neurodegenerative Disease

Apabetalone (RVX-208) inhibits key pro-atherogenic mediators and pathways in diabetes and inflammatory conditions; in vitro and in patients

Apabetalone, an Epigenetic BET Inhibitor in a Phase 3 Trial, Inhibits Vascular Inflammation and Cellular Adhesion Leading to Beneficial Outcomes in CVD Patients

Apabetalone (RVX-208) Suppresses Expression of Key Vascular Inflammation Markers in Monocytes, Endothelial Cells and LPS-Challenged Mouse Liver and Monocyte Adhesiveness to Activated Endothelial Cells