Koo,

Great questions. If I recall, the MoCA testing is just an exploratory substudy of BETonMACE. Results will be used to inform the design of a follow up cognition trial, which right now is proposed as a Phase 2 vascular cognitive dementia trial. Seeing as BETonMACE patients all have experienced a recent ACS event within 90 days, and seeing as origins of vascular cognitive dementia are due to interrupted blood flow to the brain, my guess is that vascular cognitive dementia is common in these BETonMACE patients with baseline MoCA of 25 or below. However, there are probably some with some degree of Alzheimer's too, and likely some with a mix of vascular cognitive dementia and Alzheimer's.

BearDownAZ