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Dialysis patients have worse kidney function than those in BETonMACE, even worse than the patients in the BETonMACE CKD substudy. So apabetalone will need to be tested for safety and efficacy first in the Phase 1/2 dialysis trial, which is ready to go after BETonMACE. Management has indicated that they want to see the BETonMACE CKD substudy data first before starting the dialysis trial so that they can tweak it if necessary.
