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Message: Re-visiting Tundup's all-time top-rated message

"Is there any way, mathematically, to convert the following to MACE events per month,..?"

Yes, but you must keep in mind that this 7.2 or 8 events per 100 patient years is a running tally of the entire trial timeline, not a snapshot in time. One would need an estimate of the number of patient years per month. For an example, let's take Tundup's conversation number and round it to 200 patient years per month that were accumulating as of around June 2018. This seems reasonable, since full enrollment is 2425 patients and 2425 divided by 12 months is 202. So let's take that 200 patient years per month and multiply it by the two example event rates. (200 patient years) X (7.2 events per 100 patient years) = 14.4 events per month. (200 patient years) X (8.0 events per 100 patient years) = 16.0 event per month. So at trial peak, it seems reasonable to expect that events were occuring at about 15 per month. Are we at peak anymore? Probably not, because over 2400 of the 2425 patients have been dosed for over 10 months now and are outside of the highest risk window of follow up. 

BearDownAZ

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