I have once been the victim of a trial where the dosed group performed as expected but the placebo group performed way above expectations with the result that the trial was not statiscally successful. Just another possibility that I truly hope is not true and probably isn't but belongs in the mix for consideration.

It's a possibility.  Participating in a study may energize some folks to improve their lifestyle choices.  You can do a lot to decrease your risk of a MACE event through diet and exercise.