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Message: Important article published yesterday (January 4), RVX208 relevant

I am sure there is a reason for it,,,,,,,,,it must be assumed to do so makes perfect sense to statisticians,,

It's not the statisticians. You should read the article I linked. 

Such events are predictable.  Companies are wise to anticipate them and adjust their N accordingly. Studies have to be sufficiently powered as well, i.e., enough subjects to demonstrate an effect (if one is really there).

 

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