One it appears may have been a winner, Cardiome Pharma....it merged with Cipher Pharma back in March, but that makes tracking the performance a little problematic and I'm not sufficiently motivated to dig into it.

But the other two were dogs, Centric Health down about 50% and Prometic down about 75%.  

https://www.cantechletter.com/2018/01/these-three-canadian-biotech-stocks-are-buys-analysts-say/

Here's another comparison chart with Cipher in place of Cardimome: