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Message: Re: BD-selectivity vs. BET protein selectivity

Good point.  Have BD2-BRD4 Stuck in brain.

Lots of the old stuff seems to mention BD2-BRD4

4 Ex

RVX 208 - Wikipedia


https://en.wikipedia.org/wiki/RVX_208
Apabetalone selectively binds to the second bromodomain (BD2). When apabetalone binds to BRD4, it impacts key biological processes that contribute to CVD ...
 

News - Resverlogix Corp.


https://www.resverlogix.com/investors/news?article=567
May 23, 2017 - The article dedicates a paragraph to RVX-208 (apabetalone) and cites ... the second bromodomain (BD2) within the BET protein called BRD4.

Resverlogix and Medison Pharma Ltd. Announce ... - Resverlogix Corp.


https://www.resverlogix.com/investors/news?article=592
Jan 8, 2018 - Resverlogix is developing apabetalone (RVX-208), a first-in-class, ... for the second bromodomain (BD2) within the BET protein called BRD4.

 

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