Re: FXR and liver transaminase related adverse events

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BearDownAZ

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Re: FXR and liver transaminase related adverse events

in response to

Re: FXR and liver transaminase related adverse events

BearDownAZ

posted on Oct 03, 2018 11:47AM

Some good background reading on the TMAO/FMO3/FXR story. FMO3 catalyzes the conversion of TMA to TMAO, FMO3 levels are significantly correlated with TMAO levels, and TMAO levels explains 11% of the variation in atherosclerosis among common inbred strains of mice.

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation