The last couple of minutes of trading in RVX was what pushed the price down, and it was on little volume and a wide bid/ask spread. I expect it would have recovered and closed at or above $4.05 had the market been open a little bit longer. I expect to see the recovery Monday morning, which is why in another post I predicted a close above $4 next trading day.
I think when there's a spike to new highs the weak hands get tempted to sell because this stock was such a dog for so long. Questrade sends me an email anytime a security in my portfolio moves 10% so I can imagine some people see the "Resverlogix has risen by 10%" email and they log in and sell a little. I hope this kind of behaviour eventually tapers off as the weak hands get replaced by momentum and long term investors.