tada,,,,,,,,,,,,these options were issued by RVX when they thought their development timeline was much more compressed, which turns out as we all well know to have been some what short sighted. Reality has actually shown us that biotechnical research and developement generally seems to take much longer than these management teams are willing to realize. I do hope these expired options are replaced for the team members but associated with future milestones more than they are for exemplary leadership......as the later would assume that milestones have been acheived......  jmo.