Koo, 

I'm not really sure what you are asking. You are correct that the primary outcome measure is time to first occurrence of 3-point MACE. Once 250 total adjudicated 3-point MACE events have occurred, the trial will be complete (unless they change protocol). Only once this occurs will the final data analysis occur and top line data reported. There is nothing magical about year end. If 250 occurs by year end then we will likely get top line data by year end. If 250 occurs in 2019, then we will get top line data in 2019. If the SSRA occurs, that will happen at 188 events. Does this clarify for you?