Narmac, that is incredibly fair....I'm basing my guesstimation on positive top-line results, but that is by no means of a sure thing.  And I think you're being optimistic with the $100 million MC if BETonMACE fails....even with BETonRenal and Fabry trials I think the stain of failure would leave an even bigger mark....frankly I think it would spell the end.  There wouldn't be enough $$$ in the til and I don't think they'd succeed in raising anymore except through CDs, otherwise known as death spiral financing.