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Message: Re: Que sera sera....
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Mar 30, 2018 05:28AM
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Apr 01, 2018 07:23AM
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Apr 03, 2018 11:16AM
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Apr 03, 2018 11:54AM
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Apr 03, 2018 03:51PM
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Apr 03, 2018 04:57PM

All pan-BET inhibitor clinical trials have been Phase 1 or 2 oncology trials. The only selective (non-pan) BET inhibitor in clinical trials that I know of are  apabetalone and ABBV-744. But ABBV-744 is only in early oncology trials. So by default, apabetalone is a) the only selective BET inhibitor in non-oncology clinical trials b) the only BET inhibitor in a cardiovascular outcomes trial; and c) the only BET inhibitor in a Phase 3 trial. I don't know of any other epigenetic (non BET inhibitors) drugs being investigated for cardiovascular indications. 

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Apr 06, 2018 02:51PM
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