"No wonder BetOnMace is taking so long...."

Aside from the slower than originally planned enrollment, is BETonMACE really taking longer than planned? Are the observed event rates so much different than anticipated such that it is taking longer than planned to observe the necessary number of events? Or is this just a gut feeling without any data to support it? If the 125 event futility analysis had occurred as originally planned, then we would have a good benchmark for projecting the total trial duration. However, without that benchmark we are just left to speculation on timelines. I'm hesitant to put too much faith in DM's timeline of 250 events by end of 2018 without having a a 50% or 75% of total event benchmark. The SSRA will be very revealing.

BDAZ