"A synonym for statistical is.... numerical,.... arithmetical. That is they need to include patient numbers from USA, and why not Canada..... I'll leave it at that."

Again, I challenge you to paint us a picture of how that would play out with requiring USA-contributed MACE events in the anticipated futility analysis. How many USA events would they need? When do you think those USA events would start rolling in? When would the necessary number of USA events occur? Can you even offer us your vision here or are you just going to continue making a baseless assumption?