There are too many unknowns to really know what the RRR in BETonMACE will be. The 55% and 77% RRR numbers were from the 5-point MACE figures. Most of the MACE events that took place in ASSURE and SUSTAIN were NOT the strict 3-point MACE variety (death, non-fatal MI, non-fatal strok). BETonMACE is powered for a 25-30% RRR in 3-point MACE. We should all be ecstatic if BETonMACE achieves 30% RRR for 3-point MACE. My opinion is that expectations of a 55% RRR in 3-point MACE are unrealistic. But I'd be happy to be wrong! BETonMACE was partially modeled after the EXAMINE trial. I discussed the EXAMINE trial, its event rate, and added variables of low-HDL and RVX-208 in a previous post of mine that attempted to project when the futility analysis would be.