FWIW hartland I reported the subject message because it did strike me as an attack....calling someone Mr. FUD (to use the short form) in my view crosses the line. I sensed some frustration in your message, mispelling BENonMACE ....as far as enrollment affecting the timing of the futility analysis...obviously the sooner the trial is fully enrolled it stands to reason that 125 and subsequently 250 events will be reached quicker the sooner the trial is full....

Peace....