"Resverlogix Corp. is an interesting resurrection story. Its lead drug, RVX-208 (apabetalone), failed in a Phase 2b clinical trial back in 2013, but then the company discovered a couple of very interesting things about the compound. Now it better understands the mechanism of action of RVX-208, which is an epigenetic inhibitor. The drug is an inhibitor of BET (bromodomain and extraterminal) domains and it was shown to increase levels of apolipoprotein A1 (ApoA1), which is a component of high-density lipoproteins (HDL/good cholesterol). This is a classic example of how a company can design a new trial from what was learned in a failed trial. Instead of giving up after the failed 324-patient Phase 2b ASSURE trial in 2013, Resverlogix made adjustments to increase its chances of success. It started a big Phase 3 trial this past October in high-risk, type 2 diabetes patients with coronary artery disease. The primary endpoint is time to first occurrence of a major cardiovascular event (MACE), with expectations that RVX-208 will also increase HDL-C, ApoA1, and large HDLs and HDL particle size. Fittingly, this Phase 3 trial is called BETonMACE.

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