the ISIN and CUSIP are new.
based on whenever this has happened before to any securities position I've held ... all goes through the same antics (because it's the same process).
without counting the clearing house(s), the amount of hell you'll go through (or not) will depend primarily on the expertise (or lack thereof) of your chosen brokerage, along with your intentions during the transition period.
fwiw, there'll be no anxiety whatsoever unless you're looking to sell; concomitantly, any buys would execute under the new ticker (which once cleared, your brokerage would thereafter merge with any existing holdings ... more-or-less whenever they decide to...)
don't sweat it.
GLTA,
R.