"For those comparing Opko with MannKind Corporation(NASDAQ: MNKD), I would point out that the situation is very different. With Mannkind, Billionaire owner Alfred Mann has added shares to the trading float via dilutive financing. He has not bought shares as Dr. Frost has been engaging in with Opko.

Many Mannkind insiders have actually been selling their shares:




Also, Mannkind has yet to produce any revenue, and still have not gotten its lead product candidate, AFREZZA inhalation powder, an ultra rapid-acting insulin therapy delivered via an inhaler approved by the FDA after receiving a complete response letter from the FDA on Jan 19, 2011.

Don't get me wrong, I am not fully bearish on Mannkind, I just list it here to show a clear contrast between 2 billionaire owners and how they approach supporting their respective companies."

http://www.bioportfolio.com/news/article/1187975/Opko-Health-Setting-Up-For-A-Big-Short-Squeeze.html