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MannKind Corp. (Nasdaq: MNKD)

MNKD is set top open the month at $1.82. The stock is currently priced -8.24% below the 50 day moving average, -25.31% below the 200 day moving average, -57.67% below the 52-week high of $4.30, and 15.92% above the 52-week low of $1.57. Results published in Blood, the official journal of the American Society of Hematology, confirm that inhibition of the IRE1α-XBP1 pathway impacts the survival of myeloma cells, suggesting a promising therapeutic option in multiple myeloma. The pre-clinical study, conducted by researchers at Dana-Farber Cancer Institute in collaboration with MNKD, confirm that blocking the XBP1 arm of the unfolded protein response with MNKD‘s novel, first-in-class IRE1a RNase domain inhibitor, MKC-3946, alone or in combination with bortezomib or 17AAG, inhibited growth in multiple myeloma cells, while leaving normal cells intact.

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