This is a small part of the Cancer Biomarkers: Current Issues & Future Directions. I would say that RECAF fits the description of the ideal biomarker.
The ideal biomarker for cancer
The ideal biomarker for cancer would have applications in
determining predisposition, early detection, assessment of
prognosis, and drug response. It would be an additional
advantage if the biomarker could also serve as a target for
drug development. Desirable characteristics of molecular
markers for cancer are shown in Table 2. No biomarker
meets these ideal characteristics. There is an urgent need for cancer biomarkers with more accurate diagnostic capability,
particularly for early-stage cancer.
Technologies for the detection of cancer
biomarkers
Several technologies have been used for the discovery of
cancer biomarkers as listed in Table 3. It is beyond the scope
of this review to describe these technologies and further
details can be found in a special report on biomarkers [1••].
Table 2.
Desirable characteristics of biomarkers for cancer.
Characteristics
Purpose
Noninvasive
Low cost
Simple to perform
Accurate*
Informative
(discriminatory)
Screening
+++
+++
+++
+++
+++
Predisposition
+++
+++
+++
+++
+++
Early detection
++
++
++
+++
+++
Prognosis
+
+
+
++
++
Drug response
+++
++
++
+++
+++
Target for drug
NA
+
NA
+++
NA
+ Low importance, ++ medium importance, +++ high importance, NA not applicable, *low rate of false-negative results.
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